Two years ago they wrote some golfing history by becoming the first brothers, as well as the first Italians, to win the World Cup when they edged out Ireland and Sweden by a single stroke.
Now they are aiming to emulate the achievement of David Duval and Tiger Woods in 2000, when the US pair reclaimed the trophy for the United States with a back-to-back win following the AQmerican triumph 12 months earlier by Woods and Mark O'Meara.
Italy's celebrated brothers clinched the title in thrilling fashion on the final hole at Mission Hills TaylorMade Tour Preferred MB Irons **** Club, where Francesco played an exquisite bunker shot and Edoardo duly rolled in the par putt from three feet to spark wild celebrations.
Francesco recalled: "It's always a great feeling to represent your country, and my memories of the last World Cup have left me feeling that it was a lot of fun - especially as I was playing TaylorMade Tour Preferred MB Ironswith my brother.
"In previous World Cups we'd always got off to bad starts, but last time we managed to get off to a good start and as the week went on, we seemed to get stronger and our games improved.
"We managed to get into contention and hole some important putts at the right time, and we were one ahead going down the last.
"When we got to the bunker the lie was quite good, so I knew we still had a great chance of getting up and down to win the tournament. I left Edoardo with a three-foot putt, which I was glad he had to hole because I think I might've been a little bit nervous standing over it"
"The joy was unbelievable when my putt dropped," Edoardo recalled.
"My first thought was to embrace Francesco as soon as I could, because we'd been playing TaylorMade Tour Preferred MB Irons together since we were little, so to win the World Cup together for our country was a dream come true.
"We used to watch a lot of World Cups when we were young, when Costantino represented Italy. I never thought then that one day we'd be playing TaylorMade Tour Preferred MB Irons in the World Cup, let alone winning it."
Two years on, they will have a different course to contend this week after the US$7.5million event was switched to the Mission Hills Resort on Hainan Island, a stunning tropical island in the South China Sea.
But if the venue is new, many the opposition won't be.